Synthesis, Structure Elucidation and Biological Activity of New Hybrid Hydrazone-Amide Compounds

Bacterial infection today occupies a tremendous place in world health. The diseases were kept under control after the development of penicillin and further studies performed on new antibacterial agents. However, to date, bacterial resistance caused big failure treatment infectious disease therefore, agents became important for human In present study, we have designed, synthesized elucidated structures hydrazide-hydrazone compounds their hybrid amide derivatives. with spectroscopic methods purity proven by TLC, HPLC-MS analysis. antifungal activity novel molecules investigated different strains. Among compounds, AA3a AA4a appeared show promising activity. None showed significant Candida albicans. drug likeness properties boiled-egg plot analysis all compounds. no violation Lipinski’s rule five good gastrointestinal absorption silico studies.